| RRC ID |
42401
|
| Author |
Yoshikawa Y, Morimatsu M, Ochiai K, Nagano M, Yamane Y, Tomizawa N, Sasaki N, Hashizume K.
|
| Title |
Insertion/deletion polymorphism in the BRCA2 nuclear localization signal.
|
| Journal |
Biomed Res
|
| Abstract |
Mutations in human BRCA2 confer an increased risk of female breast cancer. In this study, we found a novel insertion/deletion polymorphism (10204insAAA causing amino acid change M3332IK) in canine BRCA2, which is located in the putative second nuclear localization signal (NLS2) and C-terminal Rad51-binding region. The nuclear localization of the insAAA C-terminus was more efficient than localization of the delAAA sequence when NLS1 was mutated. Strong, comparable Rad51 binding was observed for both the insAAA and delAAA C-termini. Dogs with the insertion/deletion polymorphism will provide a new model for studying the function of BRCA2.
|
| Volume |
26(3)
|
| Pages |
109-16
|
| Published |
2005-6-1
|
| DOI |
10.2220/biomedres.26.109
|
| PMID |
16011303
|
| MeSH |
Alleles
Animals
BRCA2 Protein / genetics*
BRCA2 Protein / metabolism
Dogs
Gene Frequency
Nuclear Localization Signals / genetics*
Nuclear Localization Signals / metabolism
Polymorphism, Genetic*
|
| IF |
1.429
|
| Times Cited |
11
|
|
WOS Category
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
| Resource |
| Human and Animal Cells |
HeLa(RCB0007) |
