論文 - 詳細
| RRC ID | 42468 |
|---|---|
| 著者 | Ito Y, Hasuda H, Kamitakahara M, Ohtsuki C, Tanihara M, Kang IK, Kwon OH. |
| タイトル | A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material. |
| ジャーナル | J Biosci Bioeng |
| Abstract |
Biodegradable and biocompatible poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a copolymer of microbial polyester, was fabricated as a nanofibrous film by electrospinning and composited with hydroxyapatite (HAp) by soaking in simulated body fluid. Compared with a PHBV cast (flat) film, the electrospun PHBV nanofibrous film was hydrophobic. However, after HAp deposition, both of the surfaces were extremely hydrophilic. The degradation rate of HAp/PHBV nanofibrous films in the presence of polyhydroxybutyrate depolymerase was very fast. Nanofiber formation increased the specific surface area and HAp enhanced the invasion of enzyme into the film by increasing surface hydrophilicity. The surface of the nanofibrous film showed enhanced cell adhesion over that of the flat film, although cell adhesion was not significantly affected by the combination with HAp. |
| 巻・号 | 100(1) |
| ページ | 43-9 |
| 公開日 | 2005-7-1 |
| DOI | 10.1263/jbb.100.43 |
| PII | S1389-1723(05)70426-6 |
| PMID | 16233849 |
| MeSH | Absorbable Implants* Animals Biocompatible Materials / analysis Biocompatible Materials / chemistry* COS Cells Cell Adhesion / physiology* Cell Culture Techniques / methods Chlorocebus aethiops Durapatite / chemistry* Electrochemistry / methods Materials Testing Nanotubes / analysis Nanotubes / chemistry* Nanotubes / ultrastructure Particle Size Polyesters / analysis Polyesters / chemistry* Rotation Surface Properties Textiles Tissue Engineering / methods* |
| IF | 2.366 |
| 引用数 | 196 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) |