RRC ID 42472
著者 Yasuda S, Itagaki S, Hirano T, Iseki K.
タイトル Expression level of ABCG2 in the placenta decreases from the mid stage to the end of gestation.
ジャーナル Biosci Biotechnol Biochem
Abstract The aim of this study was to elucidate the expression pattern of ABCG2 in the placenta from the mid stage to the end of gestation. rABCG2 expression was investigated in rats on the 14th gestation day (gd) and the 20th gd. Expression of the rABCG2 gene and expression of rABCG2 protein in the placenta were detected on gd 14 by RT-PCR and Western blot analysis respectively. The expression level of rABCG2 on gd 20 was less than that on gd 14. We investigated whether progesterone, secreted from the placenta, regulates the expression of ABCG2 in BeWo cells. Expression levels of the ABCG2 gene and protein in BeWo cells were decreased by progesterone treatment. We conclude that progesterone plays a role in reduction in the expression level of ABCG2 in the placenta with the advance of gestation from the mid stage to the end of gestation.
巻・号 69(10)
ページ 1871-6
公開日 2005-10-1
DOI 10.1271/bbb.69.1871
PII JST.JSTAGE/bbb/69.1871
PMID 16244436
MeSH ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters / genetics* Animals Cell Line Cell Survival / drug effects Female Gene Expression Regulation / drug effects Gene Expression Regulation / physiology* Gestational Age* Mitoxantrone / pharmacology Placenta / metabolism* Pregnancy / metabolism* Progesterone / blood Progesterone / pharmacology RNA, Messenger / analysis Rats Rats, Wistar
IF 1.516
引用数 43
WOS 分野 CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞