Reference - Detail
| RRC ID | 42492 |
|---|---|
| Author | Kuramochi K, Matsui R, Matsubara Y, Nakai J, Sunoki T, Arai S, Nagata S, Nagahara Y, Mizushina Y, Ikekita M, Kobayashi S. |
| Title | Apoptosis-inducing effect of epolactaene derivatives on BALL-1 cells. |
| Journal | Bioorg Med Chem |
| Abstract |
Epolactaene, a neuritogenic compound in human neuroblastoma SH-SY5Y, induces apoptosis in a human leukemia B-cell line, BALL-1. The apoptosis-inducing activities of 34 epolactaene derivatives, including those of the newly synthesized alpha-alkyl-alpha,beta-epoxy-gamma-lactam derivative and cyclopropane derivatives, were also tested. The structure-activity relationships of the epolactaene derivatives as an inducer of apoptosis are described. The alpha-acyl-alpha,beta-epoxy-gamma-lactam moiety as well as the hydrophobicity derived from the long alkyl side chain are both important for activity. Compound 1e displayed the strongest activity among all the synthesized compounds with an IC50 value of 0.70 microM. |
| Volume | 14(7) |
| Pages | 2151-61 |
| Published | 2006-4-1 |
| DOI | 10.1016/j.bmc.2005.10.057 |
| PII | S0968-0896(05)01055-2 |
| PMID | 16298530 |
| MeSH | Apoptosis / drug effects* Cell Line, Tumor Cell Survival / drug effects Drug Screening Assays, Antitumor Epoxy Compounds / chemical synthesis Epoxy Compounds / chemistry Epoxy Compounds / pharmacology Humans Hydrolysis Leukemia, B-Cell / drug therapy* Molecular Structure Polyenes / chemical synthesis Polyenes / chemistry Polyenes / pharmacology Stereoisomerism Structure-Activity Relationship |
| IF | 3.073 |
| Times Cited | 22 |
| WOS Category | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | BALL-1 |