論文 - 詳細
| RRC ID | 42626 |
|---|---|
| 著者 | Kitajima M, Nakamura T, Kogure N, Ogawa M, Mitsuno Y, Ono K, Yano S, Aimi N, Takayama H. |
| タイトル | Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells. |
| ジャーナル | J Nat Prod |
| Abstract |
Four new gelsedine-type indole alkaloids (1-4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids. The structures were determined as 14-acetoxygelsenicine (1), 14-acetoxy-15-hydroxygelsenicine (2), 14-hydroxy-19-oxogelsenicine (3), and 14-acetoxygelselegine (4), respectively, by spectroscopic analysis. The cytotoxic effects of 14 Gelsemium alkaloids including two new compounds (1, 2) were evaluated using the A431 human epidermoid carcinoma cell line. Of these, the gelsedine-type alkaloids 14-acetoxy15-hydroxygelsenicine (2) [corrected] 14,15-dihydroxygelsenicine (5), gelsedine (7), and gelsemicine (8) showed potent cytotoxic effects. |
| 巻・号 | 69(4) |
| ページ | 715-8 |
| 公開日 | 2006-4-1 |
| DOI | 10.1021/np060016o |
| PMID | 16643063 |
| MeSH | Alkaloids* / chemistry Alkaloids* / classification Alkaloids* / isolation & purification Alkaloids* / pharmacology Drug Screening Assays, Antitumor Gelsemium / chemistry* Humans Indole Alkaloids* / chemistry Indole Alkaloids* / classification Indole Alkaloids* / isolation & purification Indole Alkaloids* / pharmacology Japan Molecular Structure Oxindoles Plants, Medicinal / chemistry* Tumor Cells, Cultured |
| IF | 3.782 |
| 引用数 | 77 |
| WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES |
| リソース情報 | |
| ヒト・動物細胞 | A431(RCB0202) |