Reference - Detail
| RRC ID | 42648 |
|---|---|
| Author | Suzuki T, Koyama Y, Hayakawa S, Munakata H, Isemura M. |
| Title | 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. |
| Journal | Biomed Res |
| Abstract |
The active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (DVD), is a potent inducer of cell differentiation and inhibits proliferation of cells such as human promyelocytic leukemia HL-60 cells. In the present study, we examined the effects of DVD on the expression of exportin-1 and exportin-t, which play essential roles in the transport of mRNA and tRNA, respectively. The results of reverse transcription-polymerase chain reaction and quantitative real-time polymerase chain reaction indicated that DVD down-regulated the gene expression of these exportins. Western blotting revealed the decreased production of these proteins in DVD-treated cells. Thus, the present findings of decreased expression of exportin-1 and exportin-t induced by DVD can be correlated to inhibition of the proliferation of HL-60 cells. |
| Volume | 27(2) |
| Pages | 89-92 |
| Published | 2006-4-1 |
| DOI | 10.2220/biomedres.27.89 |
| PII | JST.JSTAGE/biomedres/27.89 |
| PMID | 16707848 |
| MeSH | Cell Proliferation Exportin 1 Protein Gene Expression Regulation, Leukemic HL-60 Cells Humans Karyopherins / genetics Karyopherins / metabolism* Leukemia, Promyelocytic, Acute / metabolism* Nucleocytoplasmic Transport Proteins / genetics Nucleocytoplasmic Transport Proteins / metabolism* RNA, Messenger / metabolism RNA, Transfer / metabolism Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / metabolism* Reverse Transcriptase Polymerase Chain Reaction Vitamin D / analogs & derivatives* Vitamin D / metabolism |
| IF | 1.429 |
| Times Cited | 12 |
| WOS Category | MEDICINE, RESEARCH & EXPERIMENTAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |