論文 - 詳細
| RRC ID | 42659 |
|---|---|
| 著者 | Yao K, Huang XD, Huang XJ, Xu ZK. |
| タイトル | Improvement of the surface biocompatibility of silicone intraocular lens by the plasma-induced tethering of phospholipid moieties. |
| ジャーナル | J Biomed Mater Res A |
| Abstract |
To improve the surface biocompatibility of the silicone intraocular lens (IOL), 2-methacryloyloxyethyl phosphorylcholine (MPC) was tethered onto the IOL through air plasma treatment. Chemical changes on the IOL surface were characterized by X-ray photoelectron spectroscopy (XPS) to confirm the covalent binding of MPC. Morphologies of the IOL surfaces were observed by scanning electron microscopy (SEM) to optimize the plasma treatment process. The hydrophilicity and biocompatibility of the control and modified IOLs were compared by the measurements of water contact angle, platelet adhesion, macrophage cell culture, and lens epithelial cell (LEC) attachment. It was found that, after the tethering of MPC, the hydrophilicity of the IOL can be improved significantly and permanently, and the platelet, macrophage, and LEC adhesion on the IOL surface are obviously suppressed, which indicated the enhancement of surface biocompatibility. |
| 巻・号 | 78(4) |
| ページ | 684-92 |
| 公開日 | 2006-9-15 |
| DOI | 10.1002/jbm.a.30741 |
| PMID | 16739174 |
| MeSH | Biocompatible Materials* Blood Platelets / cytology Cell Adhesion Humans Lens, Crystalline / cytology Lenses, Intraocular* Macrophages / cytology Surface Properties |
| IF | 3.525 |
| 引用数 | 54 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | SRA 01/04(RCB1591 |