Reference - Detail
| RRC ID | 42692 |
|---|---|
| Author | Iliya I, Akao Y, Matsumoto K, Nakagawa Y, Zulfiqar A, Ito T, Oyama M, Murata H, Tanaka T, Nozawa Y, Iinuma M. |
| Title | Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells. |
| Journal | Biol Pharm Bull |
| Abstract |
Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC(50) of 10.0 microM and 12.2 microM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells. |
| Volume | 29(7) |
| Pages | 1490-2 |
| Published | 2006-7-1 |
| DOI | 10.1248/bpb.29.1490 |
| PII | JST.JSTAGE/bpb/29.1490 |
| PMID | 16819196 |
| MeSH | Apoptosis / drug effects* Cell Division / drug effects* DNA Fragmentation / drug effects DNA, Neoplasm / drug effects DNA, Neoplasm / genetics Ferns* HL-60 Cells Humans Indonesia Kinetics Plant Extracts / pharmacology* Plant Roots Plant Stems Stilbenes / pharmacology* |
| IF | 1.863 |
| Times Cited | 11 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |