| RRC ID |
42700
|
| Author |
Osaki T, Takagi S, Hoshino Y, Okumura M, Fujinaga T.
|
| Title |
Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models.
|
| Journal |
Cancer Lett
|
| Abstract |
Photodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3h or 15min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval PDT enhanced the antitumor effect by damaging tumor vasculature.
|
| Volume |
248(1)
|
| Pages |
47-57
|
| Published |
2007-4-8
|
| DOI |
10.1016/j.canlet.2006.05.021
|
| PII |
S0304-3835(06)00402-2
|
| PMID |
16837129
|
| MeSH |
Animals
Antineoplastic Agents / therapeutic use
Blood Flow Velocity / drug effects
Blotting, Western
Cell Line, Tumor
Female
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Laser-Doppler Flowmetry
Mice
Mice, Inbred C3H
Mice, Inbred DBA
Neoplasms, Experimental / blood supply
Neoplasms, Experimental / drug therapy*
Neoplasms, Experimental / pathology
Neovascularization, Pathologic / drug therapy*
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / pathology
Photochemotherapy / methods*
Porphyrins / therapeutic use*
Time Factors
Tumor Burden / drug effects
Verteporfin
|
| IF |
7.36
|
| Times Cited |
12
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
|
