Reference - Detail
| RRC ID | 42746 |
|---|---|
| Author | Akazawa H, Akihisa T, Taguchi Y, Banno N, Yoneima R, Yasukawa K. |
| Title | Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense. |
| Journal | Biol Pharm Bull |
| Abstract |
Melanogenesis inhibitory and free radical scavenging activities of nine cyclic (1-9) and one acyclic diarylheptanoids (10), and two phenolic compounds, (+)-rhododendrol (11) and (+)-catechin (12), isolated from the ethyl acetate-soluble fraction of the MeOH extract of the bark of Acer nikoense MAXIM. (Aceraceae) were examined. Upon evaluation of compounds 1-12 on the melanogenesis in the B16 melanoma cells, two compounds, 2 and 8, exhibited marked inhibitory activity with 55.6% and 46.8% reduction, respectively, of melanin content at 25 microg/ml without inhibition of cell proliferation. In addition, upon an evaluation of eleven compounds, 1-7 and 9-12 against the scavenging activities of free radicals (against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical), compound 12 (IC(50) 9.0 microgM) followed by compounds 1, 3, 4, and 6 (IC(50) 40.2-44.0 microgM) showed potent scavenging activities. |
| Volume | 29(9) |
| Pages | 1970-2 |
| Published | 2006-9-1 |
| DOI | 10.1248/bpb.29.1970 |
| PII | JST.JSTAGE/bpb/29.1970 |
| PMID | 16946520 |
| MeSH | Acer / chemistry* Animals Diarylheptanoids / pharmacology* Free Radical Scavengers / pharmacology* Melanins / biosynthesis* Mice Phenols / pharmacology* Plant Bark / chemistry* Plant Extracts / pharmacology* |
| IF | 1.863 |
| Times Cited | 53 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | B16 |