| RRC ID |
42848
|
| Author |
Osaki T, Takagi S, Hoshino Y, Okumura M, Fujinaga T.
|
| Title |
Intracellular localization and concentration as well as photodynamic effects of benzoporphyrin derivative monoacid ring A in four types of rodent tumor cells.
|
| Journal |
Cancer Lett
|
| Abstract |
The relative sensitivities of different tumor cells to photodynamic therapy (PDT) with benzoporphyrin derivative monoacid ring A (BPD-MA) were compared in the four tumor cells. A good correlation was observed between the cell survival at 0.1 microg/ml of BPD-MA and sensitizer uptake/10(6) cells (r = -0.99) or the plating efficiency of cells (r = 0.99). At 3 h after the irradiation, a significant difference was observed in the proportion of apoptotic cells among the four tumor cells (p = 0.024). In conclusion, cell responses to PDT depend on the several factors such as the cell line, photosensitizer dose, and fluence.
|
| Volume |
243(2)
|
| Pages |
281-92
|
| Published |
2006-11-18
|
| DOI |
10.1016/j.canlet.2005.11.044
|
| PII |
S0304-3835(05)01034-7
|
| PMID |
16412570
|
| MeSH |
Animals
Apoptosis / drug effects*
Apoptosis / radiation effects*
Biological Transport
Cell Line, Tumor
Cell Survival / drug effects
Cell Survival / radiation effects
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Intracellular Space / metabolism
Mice
Microscopy, Confocal
Neoplasms / metabolism
Neoplasms / pathology
Porphyrins / pharmacokinetics
Porphyrins / pharmacology*
Propidium / chemistry
Rats
Staining and Labeling / methods
Verteporfin
|
| Times Cited |
23
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
|
| Resource |
| Human and Animal Cells |
LM8(RCB1450) |
