論文 - 詳細
| RRC ID | 42860 |
|---|---|
| 著者 | Matsuhashi T, Otaka M, Odashima M, Jin M, Komatsu K, Wada I, Horikawa Y, Ohba R, Oyake J, Hatakeyama N, Watanabe S. |
| タイトル | Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat. |
| ジャーナル | Dig Dis Sci |
| Abstract |
The aim of this study was to investigate the protective action of rice extract on ethanol-induced mucosal damage in vivo and wound healing of epithelial cells in vitro. Also, the effect of rice extract on gastric mucosal prostaglandin E(2) level, HSP72 expression, gastric acid secretion, and contribution of vanilloid receptor-mediated action was studied. In addition, using cultured gastric mucosal cells (RGM-1), the effect of rice extract on cytoprotection and wound healing of epithelial cells was evaluated. Rice extract significantly reduced gastric mucosal damage produced by ethanol in vivo, and heat treatment (80 degrees C, 3 min) of this agent did not alter its protective effect. Rice extract also protected RGM-1 from ethanol-induced damage in a dose-dependent manner. Rice extract accelerated wound healing of gastric epithelial cells. Our results demonstrate that rice extract could be an alternative ulcer treatment that provides cytoprotection and enhancement of wound healing not dependent on acid secretion, prostaglandin E(2) level, HSP72 expression, or vanilloid receptors. |
| 巻・号 | 52(2) |
| ページ | 434-41 |
| 公開日 | 2007-2-1 |
| DOI | 10.1007/s10620-006-9571-9 |
| PMID | 17216574 |
| MeSH | Animals Anti-Ulcer Agents / pharmacology* Cell Line Cell Survival / drug effects Cytoprotection / drug effects* Dinoprostone / metabolism Disease Models, Animal Dose-Response Relationship, Drug Epithelial Cells / drug effects Ethanol / toxicity Gastric Acid / metabolism Gastric Mucosa / drug effects* Gastric Mucosa / metabolism Gastric Mucosa / pathology HSP72 Heat-Shock Proteins / metabolism Male Oryza* Plant Extracts / pharmacology Rats Rats, Sprague-Dawley Stomach Ulcer / chemically induced Stomach Ulcer / metabolism Stomach Ulcer / pathology Stomach Ulcer / physiopathology Stomach Ulcer / prevention & control* TRPV Cation Channels / metabolism Time Factors Wound Healing / drug effects |
| IF | 2.751 |
| 引用数 | 12 |
| WOS 分野 | GASTROENTEROLOGY & HEPATOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RGM1(RCB0876) |