論文 - 詳細
| RRC ID | 42870 |
|---|---|
| 著者 | Chang X, Li W, Jia Z, Satou T, Fushiya S, Koike K. |
| タイトル | Biologically active triterpenoid saponins from Ardisia japonica. |
| ジャーナル | J Nat Prod |
| Abstract |
Eleven new triterpenoid saponins, ardisianosides A (1), B (2), C (4), D (5), E (6), F (7), G (15), H (16), I (17), J (18), and K (19), together with 10 known saponins, were isolated from the whole plants of Ardisia japonica. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR and MS studies coupled with chemical degradations. The cytotoxic activities of saponins 1-21 are reported against three human cancer cell lines, namely, HL-60 myeloid leukemia, KATO-III stomach adenocarcinoma, and A549 lung adenocarcinoma cells. |
| 巻・号 | 70(2) |
| ページ | 179-87 |
| 公開日 | 2007-2-1 |
| DOI | 10.1021/np0604681 |
| PMID | 17243725 |
| MeSH | Antineoplastic Agents, Phytogenic* / chemistry Antineoplastic Agents, Phytogenic* / isolation & purification Antineoplastic Agents, Phytogenic* / pharmacology Ardisia / chemistry* Drug Screening Assays, Antitumor Humans Japan Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal / chemistry* Saponins* / chemistry Saponins* / isolation & purification Saponins* / pharmacology Triterpenes* / chemistry Triterpenes* / isolation & purification Triterpenes* / pharmacology |
| IF | 3.782 |
| 引用数 | 52 |
| WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) Kato III(RCB2088) HL60(RCB0041) |