| RRC ID |
42874
|
| Author |
Koide N, Morikawa A, Ito H, Sugiyama T, Hassan F, Islam S, Tumurkhuu G, Mori I, Yoshida T, Yokochi T.
|
| Title |
Defective responsiveness of CD5+ B1 cells to lipopolysaccharide in cytokine production.
|
| Journal |
J Endotoxin Res
|
| Abstract |
Previously, we found that mouse TH2.52 cells possess the characteristic of CD5(+) B1 cells and proliferate in response to lipopolysaccharide (LPS). The effect of LPS on cytokine production by TH2.52 B1 cells was studied. TH2.52 cells constitutively produced a small amount of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and TNF-alpha and IL-6 production was markedly enhanced by LPS stimulation. Although interferon (IFN)-gamma caused the production of various cytokines, such as IL-2, IL-4, IL-6 and TNF-alpha in TH2.52 cells, LPS did not cause the production of such cytokines. LPS did not induce IFN-beta production in TH2.52 cells and TH2.52 cells lacked the expression of several molecules participating in the MyD88-independent pathway in LPS signaling. Defective responsiveness of TH2.52 B1 cells to LPS in cytokine production might be responsible for the failure of IFN-beta production due to the lack of molecules participating in the MyD88-independent pathway.
|
| Volume |
12(6)
|
| Pages |
346-51
|
| Published |
2006-1-1
|
| DOI |
10.1179/096805106X118924
|
| PMID |
17254388
|
| MeSH |
Animals
Antigens, CD / immunology*
B-Lymphocytes / immunology*
CD5 Antigens / immunology*
Cell Division / drug effects
Cell Line
Cytokines / biosynthesis
Lipopolysaccharides / toxicity*
Mice
Spleen / immunology
|
| Times Cited |
1
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
MICROBIOLOGY
IMMUNOLOGY
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
