| RRC ID |
42929
|
| 著者 |
Kushida S, Ohmae H, Kamma H, Totsuka R, Matsumura M, Takeuchi A, Saiki I, Yanagawa T, Onizawa K, Ishii T, Ohn T.
|
| タイトル |
Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with lewis lung carcinoma and B16 melanoma cells.
|
| ジャーナル |
Int J Hyperthermia
|
| Abstract |
In cancer immunotherapies combined with hyperthermia, one or two cytokines have been tested to augment the anti-tumor effect. However, the therapies have not shown sufficient improvement. The aim of this study is to find a new potent tumor immunotherapy in order to augment antitumor effect of hyperthermia by the cytokine cocktails in vivo. We used a combination therapy of local hyperthermia (LH) and various cytokine cocktails composed of IFNs (IFN-alpha, -beta, and -gamma), Thl cytokines (IL-2, -12, -15, and -18), a Th2 cytokine (IL-4), inflammatory cytokines (IL-lalpha and TNF-alpha), and dendritic cell-inducible cytokines (IL-3 and GM-CSF). These cytokines in a proper combination augmented the anti-tumor effect of LH and prolonged survival time in Lewis lung carcinoma or B16 melanoma significantly. Moreover, the 12-cytokine cocktail suppressed B 16 metastasis to the lung and lymph nodes, and complete regression of the tumors without regrowth occurred in 3 of 5 mice. In the cured three B16 mice, there was hyperplasia of lymphatic organs with many CD3-positive T lymphocytes. The most effective cytokine combination should be able to augment the anti-tumor effect of other therapies besides hyperthermia that induce the necrosis of tumor cells.
|
| 巻・号 |
22(8)
|
| ページ |
699-712
|
| 公開日 |
2006-12-1
|
| DOI |
10.1080/02656730601088508
|
| PMID |
17390999
|
| MeSH |
Animals
Carcinoma, Lewis Lung / therapy*
Combined Modality Therapy
Cytokines / therapeutic use*
Disease Models, Animal
Hyperthermia, Induced*
Immunotherapy, Active / methods*
Male
Melanoma, Experimental / therapy*
Mice
Survival Analysis
Treatment Outcome
|
| IF |
3.574
|
| 引用数 |
3
|
|
WOS 分野
|
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
LLC(RCB0558) |
