RRC ID 42931
Author Efdi M, Itoh T, Akao Y, Nozawa Y, Koketsu M, Ishihara H.
Title The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium.
Journal Bioorg Med Chem
Abstract Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline chloride as a quaternary alkaloid compound. The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells.
Volume 15(11)
Pages 3667-71
Published 2007-6-1
DOI 10.1016/j.bmc.2007.03.051
PII S0968-0896(07)00250-7
PMID 17400462
MeSH Alkaloids / chemistry Alkaloids / isolation & purification Alkaloids / pharmacology Annonaceae / metabolism* Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Cell Proliferation / drug effects Coumaric Acids / chemistry Coumaric Acids / isolation & purification Coumaric Acids / pharmacology Humans Isocoumarins / chemistry Isocoumarins / isolation & purification Isocoumarins / pharmacology Lactones / chemistry Lactones / isolation & purification Lactones / pharmacology* Naphthalenes / chemistry Naphthalenes / isolation & purification Naphthalenes / pharmacology* Ochratoxins / chemistry Ochratoxins / isolation & purification Ochratoxins / pharmacology Tumor Cells, Cultured Tyramine / analogs & derivatives Tyramine / chemistry Tyramine / isolation & purification Tyramine / pharmacology
IF 3.073
Times Cited 15
WOS Category CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Human and Animal Cells HL60(RCB0041)