Reference - Detail
| RRC ID | 42931 |
|---|---|
| Author | Efdi M, Itoh T, Akao Y, Nozawa Y, Koketsu M, Ishihara H. |
| Title | The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium. |
| Journal | Bioorg Med Chem |
| Abstract |
Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline chloride as a quaternary alkaloid compound. The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells. |
| Volume | 15(11) |
| Pages | 3667-71 |
| Published | 2007-6-1 |
| DOI | 10.1016/j.bmc.2007.03.051 |
| PII | S0968-0896(07)00250-7 |
| PMID | 17400462 |
| MeSH | Alkaloids / chemistry Alkaloids / isolation & purification Alkaloids / pharmacology Annonaceae / metabolism* Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Cell Proliferation / drug effects Coumaric Acids / chemistry Coumaric Acids / isolation & purification Coumaric Acids / pharmacology Humans Isocoumarins / chemistry Isocoumarins / isolation & purification Isocoumarins / pharmacology Lactones / chemistry Lactones / isolation & purification Lactones / pharmacology* Naphthalenes / chemistry Naphthalenes / isolation & purification Naphthalenes / pharmacology* Ochratoxins / chemistry Ochratoxins / isolation & purification Ochratoxins / pharmacology Tumor Cells, Cultured Tyramine / analogs & derivatives Tyramine / chemistry Tyramine / isolation & purification Tyramine / pharmacology |
| IF | 3.073 |
| Times Cited | 15 |
| WOS Category | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |