| RRC ID |
42975
|
| 著者 |
Matsui K, Sasaki Y, Komatsu T, Mukai M, Kikuchi J, Aoyama Y.
|
| タイトル |
RNAi gene silencing using cerasome as a viral-size siRNA-carrier free from fusion and cross-linking.
|
| ジャーナル |
Bioorg Med Chem Lett
|
| Abstract |
Surface-rigidified cerasomes (ceramic-coated liposomes) are neither fused nor cross-linked when bound to siRNA (short duplex RNA) but not to plasmid DNA (long duplex DNA) which induces cross-linking. Non-ceramic reference liposomes are easily fused by the siRNA. The cerasome can thus be used as a viral-size siRNA-carrier in a wide range of concentration for RNAi silencing of exogenous and endogenous genes.
|
| 巻・号 |
17(14)
|
| ページ |
3935-8
|
| 公開日 |
2007-7-15
|
| DOI |
10.1016/j.bmcl.2007.04.097
|
| PII |
S0960-894X(07)00527-6
|
| PMID |
17502138
|
| MeSH |
Base Sequence
Gene Silencing*
Liposomes
Plasmids
RNA Interference*
RNA, Small Interfering*
|
| IF |
2.572
|
| 引用数 |
20
|
|
WOS 分野
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa(RCB0007) |
