論文 - 詳細
| RRC ID | 42987 |
|---|---|
| 著者 | Hirata N, Naruto S, Ohguchi K, Akao Y, Nozawa Y, Iinuma M, Matsuda H. |
| タイトル | Mechanism of the melanogenesis stimulation activity of (-)-cubebin in murine B16 melanoma cells. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
(-)-Cubebin showed a melanogenesis stimulation activity in a concentration-dependent manner in murine B16 melanoma cells without any significant effects on cell proliferation. Tyrosinase activity was increased at 24-72 h after addition of cubebin to B16 cells, and then intracellular melanin amount was increased at 48-96 h after the treatment. The expression levels of tyrosinase were time-dependently enhanced after the treatment with cubebin. At the same time, the expression levels of tyrosinase mRNA were also increased after addition of cubebin. Furthermore Western blot analysis revealed that cubebin elevated the level of phosphorylation of p38 mitogen-activated protein kinase (MAPK). SB203580, a selective inhibitor of p38 MAPK, completely blocked cubebin-induced expression of tyrosinase mRNA in B16 cells. These results suggested that cubebin increased melanogenesis in B16 cells through the enhancement of tyrosinase expression mediated by activation of p38 MAPK. |
| 巻・号 | 15(14) |
| ページ | 4897-902 |
| 公開日 | 2007-7-15 |
| DOI | 10.1016/j.bmc.2007.04.046 |
| PII | S0968-0896(07)00373-2 |
| PMID | 17521910 |
| MeSH | Animals Cell Line, Tumor Cell Proliferation / drug effects Gene Expression Regulation, Enzymologic / drug effects Gene Expression Regulation, Enzymologic / genetics Imidazoles / pharmacology Lignans / pharmacology* Melanins / biosynthesis* Melanoma / metabolism* Melanoma / pathology Mice Monophenol Monooxygenase / genetics Monophenol Monooxygenase / metabolism Phosphorylation / drug effects Pyridines / pharmacology RNA, Messenger / genetics p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 3.073 |
| 引用数 | 56 |
| WOS 分野 | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |