RRC ID 4301
Author Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K.
Title Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.
Journal Cell Metab
Abstract We investigated serotonin signaling in C. elegans as a paradigm for neural regulation of energy balance and found that serotonergic regulation of fat is molecularly distinct from feeding regulation. Serotonergic feeding regulation is mediated by receptors whose functions are not required for fat regulation. Serotonergic fat regulation is dependent on a neurally expressed channel and a G protein-coupled receptor that initiate signaling cascades that ultimately promote lipid breakdown at peripheral sites of fat storage. In turn, intermediates of lipid metabolism generated in the periphery modulate feeding behavior. These findings suggest that, as in mammals, C. elegans feeding behavior is regulated by extrinsic and intrinsic cues. Moreover, obesity and thinness are not solely determined by feeding behavior. Rather, feeding behavior and fat metabolism are coordinated but independent responses of the nervous system to the perception of nutrient availability.
Volume 7(6)
Pages 533-44
Published 2008-6-1
DOI 10.1016/j.cmet.2008.04.012
PII S1550-4131(08)00144-7
PMID 18522834
PMC PMC2495008
MeSH Adipose Tissue / metabolism* Animals Caenorhabditis elegans / metabolism* Energy Metabolism Feeding Behavior* Lipid Metabolism Serotonin / physiology*
IF 21.567
Times Cited 117
C.elegans tm1325 tm2146