論文 - 詳細
| RRC ID | 4301 |
|---|---|
| 著者 | Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. |
| タイトル | Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. |
| ジャーナル | Cell Metab |
| Abstract |
We investigated serotonin signaling in C. elegans as a paradigm for neural regulation of energy balance and found that serotonergic regulation of fat is molecularly distinct from feeding regulation. Serotonergic feeding regulation is mediated by receptors whose functions are not required for fat regulation. Serotonergic fat regulation is dependent on a neurally expressed channel and a G protein-coupled receptor that initiate signaling cascades that ultimately promote lipid breakdown at peripheral sites of fat storage. In turn, intermediates of lipid metabolism generated in the periphery modulate feeding behavior. These findings suggest that, as in mammals, C. elegans feeding behavior is regulated by extrinsic and intrinsic cues. Moreover, obesity and thinness are not solely determined by feeding behavior. Rather, feeding behavior and fat metabolism are coordinated but independent responses of the nervous system to the perception of nutrient availability. |
| 巻・号 | 7(6) |
| ページ | 533-44 |
| 公開日 | 2008-6-1 |
| DOI | 10.1016/j.cmet.2008.04.012 |
| PII | S1550-4131(08)00144-7 |
| PMID | 18522834 |
| PMC | PMC2495008 |
| MeSH | Adipose Tissue / metabolism* Animals Caenorhabditis elegans / metabolism* Energy Metabolism Feeding Behavior* Lipid Metabolism Serotonin / physiology* |
| IF | 21.567 |
| 引用数 | 117 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Blogs |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1325 tm2146 |