| RRC ID |
43012
|
| 著者 |
Enoki T, Ohnogi H, Nagamine K, Kudo Y, Sugiyama K, Tanabe M, Kobayashi E, Sagawa H, Kato I.
|
| タイトル |
Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.
|
| ジャーナル |
J Agric Food Chem
|
| Abstract |
Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice.
|
| 巻・号 |
55(15)
|
| ページ |
6013-7
|
| 公開日 |
2007-7-25
|
| DOI |
10.1021/jf070720q
|
| PMID |
17583349
|
| MeSH |
Angelica / chemistry*
Animals
Chalcones / isolation & purification*
Chalcones / therapeutic use*
Diabetes Mellitus / prevention & control
Hypoglycemic Agents / isolation & purification*
Hypoglycemic Agents / therapeutic use*
Insulin / pharmacology
Male
Mice
PPAR gamma / drug effects
Plant Extracts / chemistry
|
| IF |
4.192
|
| 引用数 |
96
|
|
WOS 分野
|
AGRICULTURE, MULTIDISCIPLINARY
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
|
| リソース情報 |
| ヒト・動物細胞 |
|
