論文 - 詳細
| RRC ID | 43012 |
|---|---|
| 著者 | Enoki T, Ohnogi H, Nagamine K, Kudo Y, Sugiyama K, Tanabe M, Kobayashi E, Sagawa H, Kato I. |
| タイトル | Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei. |
| ジャーナル | J Agric Food Chem |
| Abstract |
Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice. |
| 巻・号 | 55(15) |
| ページ | 6013-7 |
| 公開日 | 2007-7-25 |
| DOI | 10.1021/jf070720q |
| PMID | 17583349 |
| MeSH | Angelica / chemistry* Animals Chalcones / isolation & purification* Chalcones / therapeutic use* Diabetes Mellitus / prevention & control Hypoglycemic Agents / isolation & purification* Hypoglycemic Agents / therapeutic use* Insulin / pharmacology Male Mice PPAR gamma / drug effects Plant Extracts / chemistry |
| IF | 4.192 |
| 引用数 | 96 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |