論文 - 詳細
| RRC ID | 43025 |
|---|---|
| 著者 | Matsushita S, Yanai Y, Fusyuku A, Fujiwara Y, Ikeda T, Ono M, Han C, Ojika M, Nohara T. |
| タイトル | Efficient conversion of tomatidine into neuritogenic pregnane derivative. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20 h at r.t., followed by pseudomerization in ice-water, gave a delta(20(22))-pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities. |
| 巻・号 | 55(7) |
| ページ | 1077-8 |
| 公開日 | 2007-7-1 |
| DOI | 10.1248/cpb.55.1077 |
| PII | JST.JSTAGE/cpb/55.1077 |
| PMID | 17603206 |
| MeSH | Acetic Acid / chemistry Acetylation Animals Cell Line Molecular Structure Nerve Growth Factors / chemical synthesis Nerve Growth Factors / chemistry Nerve Growth Factors / pharmacology Neurites / drug effects* PC12 Cells Plant Components, Aerial / chemistry Pregnanes / chemical synthesis* Pregnanes / chemistry* Pregnanes / pharmacology Pyridines / chemistry Rats Solanum lycopersicum / chemistry* Tomatine / analogs & derivatives* Tomatine / chemistry |
| IF | 1.416 |
| 引用数 | 2 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | |