論文 - 詳細
| RRC ID | 43055 |
|---|---|
| 著者 | Ishida I, Kohda C, Yanagawa Y, Miyaoka H, Shimamura T. |
| タイトル | Epigallocatechin gallate suppresses expression of receptor activator of NF-kappaB ligand (RANKL) in Staphylococcus aureus infection in osteoblast-like NRG cells. |
| ジャーナル | J Med Microbiol |
| Abstract |
Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-kappaB ligand (RANKL), osteoblasts were infected with Staphylococcus aureus and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment. |
| 巻・号 | 56(Pt 8) |
| ページ | 1042-1046 |
| 公開日 | 2007-8-1 |
| DOI | 10.1099/jmm.0.47029-0 |
| PMID | 17644710 |
| MeSH | Animals Catechin / analogs & derivatives* Catechin / pharmacology Cytokines / drug effects Cytokines / metabolism Mice Osteoblasts / drug effects Osteoblasts / immunology Osteoblasts / metabolism* Osteoblasts / microbiology Protease Inhibitors / pharmacology* RANK Ligand / metabolism* Staphylococcal Infections / immunology Staphylococcal Infections / metabolism* Staphylococcus aureus* |
| IF | 2.156 |
| 引用数 | 17 |
| WOS 分野 | MICROBIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |