論文 - 詳細
| RRC ID | 43070 |
|---|---|
| 著者 | Simon CG Jr, Stephens JS, Dorsey SM, Becker ML. |
| タイトル | Fabrication of combinatorial polymer scaffold libraries. |
| ジャーナル | Rev Sci Instrum |
| Abstract |
We have designed a novel combinatorial research platform to help accelerate tissue engineering research. Combinatorial methods combine many samples into a single specimen to enable accelerated experimentation and discovery. The platform for fabricating combinatorial polymer scaffold libraries can be used to rapidly identify scaffold formulations that maximize tissue formation. Many approaches for screening cell-biomaterial interactions utilize a two-dimensional format such as a film or surface to present test substrates to cells. However, cells in vivo exist in a three-dimensional milieu of extracellular matrix and cells in vitro behave more naturally when cultured in a three-dimensional environment than when cultured on a two-dimensional surface. Thus, we have designed a method for fabricating combinatorial biomaterial libraries where the materials are presented to cells in the form of three-dimensional, porous, salt-leached, polymer scaffolds. Many scaffold variations and compositions can be screened in a single experiment so that optimal scaffold formulations for tissue formation can be rapidly identified. In summary, we have developed a platform technology for fabricating combinatorial polymer scaffold libraries that can be used to screen cell response to materials in a three-dimensional, scaffold format. |
| 巻・号 | 78(7) |
| ページ | 072207 |
| 公開日 | 2007-7-1 |
| DOI | 10.1063/1.2755761 |
| PMID | 17672738 |
| MeSH | Biocompatible Materials / chemistry* Cell Culture Techniques / instrumentation* Cell Culture Techniques / methods Combinatorial Chemistry Techniques / instrumentation* Combinatorial Chemistry Techniques / methods Equipment Design Equipment Failure Analysis Lactic Acid / chemistry* Materials Testing / instrumentation* Materials Testing / methods Microfluidic Analytical Techniques / instrumentation Microfluidic Analytical Techniques / methods Polyesters Polymers / chemistry* Robotics / instrumentation* Robotics / methods Tissue Engineering / instrumentation* Tissue Engineering / methods |
| IF | 1.48 |
| 引用数 | 39 |
| WOS 分野 | INSTRUMENTS & INSTRUMENTATION PHYSICS, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |