| RRC ID |
43095
|
| 著者 |
Kimura Y, Sumiyoshi M, Suzuki T, Suzuki T, Sakanaka M.
|
| タイトル |
Effects of water-soluble low-molecular-weight beta-1, 3-D-glucan (branch beta-1, 6) isolated from Aureobasidium pullulans 1A1 strain black yeast on restraint stress in mice.
|
| ジャーナル |
J Pharm Pharmacol
|
| Abstract |
It is well known that different stress paradigms are able to rapidly induce corticosterone production and immune function through the activation of the hypothalamic-pituitary-adrenal axis. It has been reported that glucocorticoids suppress natural killer (NK) activity and interleukin (IL)-1 production and, on the other hand, that IL-1 and IL-6 stimulate the release of corticotrophin-releasing-hormone from the rat hypothalamus. Moreover, it has been reported that IL-12 plays a central role in the initiation of cell-mediated immunity, directly and via its induction of interferon (IFN)-gamma and activation of NK cells. In this study, we examined the effects of water-soluble low-molecular-weight beta-glucan isolated from Aureobasidium pullulans 1A1 strain on the corticosterone levels and immune function, such as NK activity and IL-6 and IL-12 production, using a restraint stress-induced mouse model. The water-soluble low-molecular-weight beta-glucan at a dose of 50 or 100 mg kg(-1) inhibited the increases in the blood corticosterone level and the reduction of NK activity induced by restraint stress. Furthermore, the water-soluble low-molecular-weight beta-glucan (100 mg kg(-1)) prevented the reduction of IL-6 and IL-12 production by splenocytes caused by restraint stress. These findings suggest that the inhibitory actions of water-soluble low-molecular-weight beta-glucan on the increase in corticosterone level and reduction of NK activity induced by restraint stress may be associated with the abrogation of the IL-6 and IL-12 reduction caused by the stress. Thus, water-soluble low-molecularweight beta-glucan may be an effective dietary supplement for the prevention of stress.
|
| 巻・号 |
59(8)
|
| ページ |
1137-44
|
| 公開日 |
2007-8-1
|
| DOI |
10.1211/jpp.59.8.0012
|
| PMID |
17725857
|
| MeSH |
Animals
Ascomycota / chemistry*
Corticosterone / blood
Dose-Response Relationship, Drug
Glucans / administration & dosage
Glucans / isolation & purification
Glucans / pharmacology*
Interleukin-12 / biosynthesis
Interleukin-6 / biosynthesis
Killer Cells, Natural / drug effects
Killer Cells, Natural / immunology
Male
Mice
Mice, Inbred BALB C
Organ Size / drug effects
Restraint, Physical
Spleen / cytology
Stress, Psychological / blood
Stress, Psychological / drug therapy*
Stress, Psychological / immunology
|
| IF |
2.571
|
| 引用数 |
20
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ヒト・動物細胞 |
YAC-1(RCB1165) |
