Reference - Detail
| RRC ID | 43122 |
|---|---|
| Author | Lo FH, Mak NK, Leung KN. |
| Title | Studies on the anti-tumor activities of the soy isoflavone daidzein on murine neuroblastoma cells. |
| Journal | Biomed Pharmacother |
| Abstract |
Daidzein (4',7-dihydroxyisoflavone) and genistein (4',5,7-trihydroxyisoflavone) are two major isoflavones found predominantly in soy beans, as well as in certain traditional Chinese medicinal herbs and tea leaves. In the past decade, there have been extensive studies on the anti-tumor effects of genistein on cancers of the breast, prostate and colon in humans. However, the anti-tumor effects of daidzein on neuronal cancer cells and its action mechanisms remain poorly understood. In this study, daidzein was shown to inhibit the proliferation of a number of murine and human neuroblastoma cell lines in vitro. Using the murine neuroblastoma Neuro-2a (BU-1) cells as the cell model, daidzein was also found to prevent the cell cycle progression to G2/M phase and induced apoptosis of the neuronal tumor cells, as measured by flow cytometry and gel electrophoresis for fragmented DNA respectively. Taken together, our results showed that daidzein could exert pleiotropic effects on the murine neuroblastoma cells, including inhibition of cell proliferation, modulation of cell cycle check point regulation, and triggering of neuronal cell apoptosis. |
| Volume | 61(9) |
| Pages | 591-5 |
| Published | 2007-10-1 |
| DOI | 10.1016/j.biopha.2007.08.021 |
| PII | S0753-3322(07)00191-6 |
| PMID | 17905565 |
| MeSH | Animals Antineoplastic Agents, Phytogenic* Apoptosis / drug effects Brain Neoplasms / drug therapy* Brain Neoplasms / pathology Cell Cycle / drug effects Cell Line, Tumor Cell Proliferation / drug effects DNA Fragmentation / drug effects Estrogens, Non-Steroidal / pharmacology* Flow Cytometry Indicators and Reagents Isoflavones / pharmacology* Kinetics Mice Neuroblastoma / drug therapy* Neuroblastoma / pathology Tetrazolium Salts Thiazoles |
| IF | 4.545 |
| Times Cited | 56 |
| WOS Category | PHARMACOLOGY & PHARMACY MEDICINE, RESEARCH & EXPERIMENTAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Policy sources |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Human and Animal Cells | LA-N-1(RCB0483) |