Reference - Detail
| RRC ID | 43219 |
|---|---|
| Author | Kuroyanagi M, Ikeda R, Gao HY, Muto N, Otaki K, Sano T, Kawahara N, Nakane T. |
| Title | Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa). |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
In the screening of biologically active constituents from woody plants, the methanol extract of leaves of Chamaecyparis obtusa showed potent neurite outgrowth-promoting activity in neuronal PC12 cells. The ethyl acetate-soluble fraction of the methanol extract showed potent activity and was separated by means of various chromatographic methods to give the two new compounds 1 and 2, as well as 11 known lignan and sesquiterpene derivatives. The structures of the new compounds were determined to be 9-O-acetyldihydrosesamin (1) and 9-O-(11-hydroxyeudesman-4-yl)dihydrosesamin (2), respectively, in NMR studies including 2D-NMR experiments. Of the 13 compounds, the known compound hinokinin (5) and the new compound 2 showed potent neurite outgrowth-promoting activity in PC 12 cells. |
| Volume | 56(1) |
| Pages | 60-3 |
| Published | 2008-1-1 |
| DOI | 10.1248/cpb.56.60 |
| PII | JST.JSTAGE/cpb/56.60 |
| PMID | 18175976 |
| MeSH | 4-Butyrolactone / analogs & derivatives* 4-Butyrolactone / chemistry 4-Butyrolactone / isolation & purification 4-Butyrolactone / pharmacology Animals Benzodioxoles Chamaecyparis / chemistry* Dioxoles / chemistry Dioxoles / isolation & purification* Dioxoles / pharmacology* Lignans / chemistry Lignans / isolation & purification* Lignans / pharmacology* Molecular Structure Nerve Growth Factor / chemistry Nerve Growth Factor / isolation & purification* Nerve Growth Factor / pharmacology* Neurites / drug effects* PC12 Cells Plant Leaves / chemistry Plants, Medicinal / chemistry* Rats |
| IF | 1.416 |
| Times Cited | 14 |
| WOS Category | CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | |