Reference - Detail
| RRC ID | 43264 |
|---|---|
| Author | Hansman GS, Oka T, Sakon N, Takeda N. |
| Title | Antigenic diversity of human sapoviruses. |
| Journal | Emerg Infect Dis |
| Abstract |
Sapovirus (SaV) is a causative agent of gastroenteritis. On the basis of capsid protein (VP1) nucleotide sequences, SaV can be divided into 5 genogroups (GI-GV), of which the GI, GII, GIV, and GV strains infect humans. SaV is uncultivable, but expression of recombinant VP1 in insect cells results in formation of viruslike particles (VLPs) that are antigenically similar to native SaV. In this study, we newly expressed SaV GII and GIV VLPs to compare genetic and antigenic relationships among all human SaV genogroups. Hyperimmune antiserum samples against VLPs reacted strongly with homologous VLPs. However, several antiserum samples weakly cross-reacted against heterologous VLPs in an antibody ELISA. Conversely, an antigen ELISA showed that VLPs of SaV in all human genogroups were antigenically distinct. These findings indicate a likely correspondence between SaV antigenicity and VP1 genogrouping and genotyping. |
| Volume | 13(10) |
| Pages | 1519-25 |
| Published | 2007-10-1 |
| DOI | 10.3201/eid1310.070402 |
| PMID | 18258001 |
| PMC | PMC2851512 |
| MeSH | Caliciviridae Infections / classification Caliciviridae Infections / genetics* Capsid Proteins / genetics Gastroenteritis / virology* Genotype Humans Phylogeny Sapovirus / classification Sapovirus / genetics* Sequence Analysis, RNA |
| IF | 6.259 |
| Times Cited | 22 |
| WOS Category | INFECTIOUS DISEASES IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Policy sources |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | |