Reference - Detail
| RRC ID | 43269 |
|---|---|
| Author | Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T. |
| Title | Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPARalpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes. |
| Volume | 369(2) |
| Pages | 333-8 |
| Published | 2008-5-2 |
| DOI | 10.1016/j.bbrc.2008.02.002 |
| PII | S0006-291X(08)00240-4 |
| PMID | 18267111 |
| MeSH | 3T3-L1 Cells Abietanes / administration & dosage* Adipocytes / drug effects Adipocytes / immunology* Animals Anti-Inflammatory Agents / administration & dosage Cell Line Inflammation / immunology* Inflammation / pathology Inflammation / prevention & control* Ligands Macrophages / drug effects Macrophages / immunology* Mice PPAR alpha / immunology* PPAR gamma / immunology* |
| IF | 2.985 |
| Times Cited | 69 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |