論文 - 詳細
| RRC ID | 43281 |
|---|---|
| 著者 | Goto K, Tanaka Y, Matsumoto Y, Ueoka R. |
| タイトル | Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid. |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Inhibitory effects of hybrid liposomes (HL) composed of L-alpha-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(20) sorbitan monooleate (Tween 80) including polyunsaturated fatty acids on the growth of human tumor cells were examined in vitro. Remarkably high inhibitory effects of HL including docosahexaenoic acid (HL-DHA) on the growth of lung carcinoma (RERF-LC-OK), colon tumor (WiDr), and stomach tumor (MKN45) cells were obtained. The induction of apoptosis by HL-DHA was revealed on the basis of fluorescence microscopic and flow cytometric analyses. |
| 巻・号 | 18(6) |
| ページ | 1880-3 |
| 公開日 | 2008-3-15 |
| DOI | 10.1016/j.bmcl.2008.02.019 |
| PII | S0960-894X(08)00199-6 |
| PMID | 18294848 |
| MeSH | Apoptosis / physiology* Cell Proliferation Colonic Neoplasms / pathology* Dimyristoylphosphatidylcholine / chemistry Dimyristoylphosphatidylcholine / pharmacology Docosahexaenoic Acids / chemistry* Docosahexaenoic Acids / pharmacology Fatty Acids, Unsaturated / chemistry Fatty Acids, Unsaturated / pharmacology Flow Cytometry Humans Lipid Peroxidation / drug effects Liposomes / chemistry Liposomes / pharmacology* Lung Neoplasms / pathology* Microscopy, Fluorescence Molecular Structure Polysorbates / pharmacology Stomach Neoplasms / pathology* Tumor Cells, Cultured |
| IF | 2.572 |
| 引用数 | 13 |
| WOS 分野 | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | MKN45(RCB1001) |