| RRC ID |
43281
|
| 著者 |
Goto K, Tanaka Y, Matsumoto Y, Ueoka R.
|
| タイトル |
Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid.
|
| ジャーナル |
Bioorg Med Chem Lett
|
| Abstract |
Inhibitory effects of hybrid liposomes (HL) composed of L-alpha-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(20) sorbitan monooleate (Tween 80) including polyunsaturated fatty acids on the growth of human tumor cells were examined in vitro. Remarkably high inhibitory effects of HL including docosahexaenoic acid (HL-DHA) on the growth of lung carcinoma (RERF-LC-OK), colon tumor (WiDr), and stomach tumor (MKN45) cells were obtained. The induction of apoptosis by HL-DHA was revealed on the basis of fluorescence microscopic and flow cytometric analyses.
|
| 巻・号 |
18(6)
|
| ページ |
1880-3
|
| 公開日 |
2008-3-15
|
| DOI |
10.1016/j.bmcl.2008.02.019
|
| PII |
S0960-894X(08)00199-6
|
| PMID |
18294848
|
| MeSH |
Apoptosis / physiology*
Cell Proliferation
Colonic Neoplasms / pathology*
Dimyristoylphosphatidylcholine / chemistry
Dimyristoylphosphatidylcholine / pharmacology
Docosahexaenoic Acids / chemistry*
Docosahexaenoic Acids / pharmacology
Fatty Acids, Unsaturated / chemistry
Fatty Acids, Unsaturated / pharmacology
Flow Cytometry
Humans
Lipid Peroxidation / drug effects
Liposomes / chemistry
Liposomes / pharmacology*
Lung Neoplasms / pathology*
Microscopy, Fluorescence
Molecular Structure
Polysorbates / pharmacology
Stomach Neoplasms / pathology*
Tumor Cells, Cultured
|
| IF |
2.572
|
| 引用数 |
13
|
|
WOS 分野
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
MKN45(RCB1001) |
