論文 - 詳細
| RRC ID | 43304 |
|---|---|
| 著者 | Ogawa K, Funaba M, Tsujimoto M. |
| タイトル | A dual role of activin A in regulating immunoglobulin production of B cells. |
| ジャーナル | J Leukoc Biol |
| Abstract |
Here, we report that activin A has a dual role in regulating Ig production of murine B cells. Activated B cells secrete activin activity by increasing activin A and decreasing follistatin expression. B cells also express type I and type II activin receptors, suggesting that they are targets of activin. Pretreatment of naïve B cells with activin A and subsequent activation by LPS resulted in increased cell growth and IgG production. In contrast, no significant effect was observed when activin A was added to naïve B cells simultaneously with LPS, indicating that activin A acts on resting but not activated B cells. In addition, activin A did not induce B cells to produce IgE, even when added prior to activation; however, in vivo antigen-specific IgE production was reduced significantly by neutralization of circulating activin A. These findings indicate that activin A plays an important role in Th2-mediated immune responses by enhancing antibody production through two distinct modes: acts directly on resting B cells to elicit full functions of activated B cells and acts indirectly on activated B cells through modulation of other immune cells. |
| 巻・号 | 83(6) |
| ページ | 1451-8 |
| 公開日 | 2008-6-1 |
| DOI | 10.1189/jlb.1007710 |
| PII | jlb.1007710 |
| PMID | 18353928 |
| MeSH | Activins / physiology* Animals B-Lymphocytes / immunology* Female Immunoglobulin E / biosynthesis Immunoglobulin G / biosynthesis Immunoglobulins / biosynthesis* Inhibin-beta Subunits Lipopolysaccharides / pharmacology Lymphocyte Activation Mice Mice, Inbred BALB C Th2 Cells / immunology Transforming Growth Factor beta1 / physiology |
| IF | 3.757 |
| 引用数 | 31 |
| WOS 分野 | IMMUNOLOGY HEMATOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | F5-5.fl(RCB0560) |