Reference - Detail
| RRC ID | 43313 |
|---|---|
| Author | Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S. |
| Title | Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation. |
| Journal | Bioorg Med Chem |
| Abstract |
Epolactaene, isolated from cultured Penicillium sp. BM 1689-P mycelium, induces neurite outgrowth and arrests the cell cycle of the human neuroblastoma cell line, SH-SY5Y, at the G1 phase. We have found that epolactaene and its derivatives induce apoptosis in the human leukemia B-cell line, BALL-1. In this study, we prepared fluorescent and biotinylated epolactaene derivatives. We characterized the cellular location and the identification of BALL-1 proteins that reacted with these compounds. The results obtained from the reaction of epolactaene or its derivative with N-acetylcysteine methyl ester indicate that these compounds induce the disulfide formation and the alpha-position of the epoxylactam core is the reactive site. |
| Volume | 16(9) |
| Pages | 5039-49 |
| Published | 2008-5-1 |
| DOI | 10.1016/j.bmc.2008.03.029 |
| PII | S0968-0896(08)00241-1 |
| PMID | 18375133 |
| MeSH | Acetylcysteine / analogs & derivatives Acetylcysteine / chemistry Biotin / chemistry* Biotinylation Cell Death / drug effects Disulfides / chemistry* Drug Screening Assays, Antitumor Epoxy Compounds / chemical synthesis Epoxy Compounds / chemistry Epoxy Compounds / pharmacology Fluorescence Humans Molecular Structure Polyenes / chemical synthesis Polyenes / chemistry Polyenes / pharmacology Stereoisomerism Tumor Cells, Cultured |
| IF | 3.073 |
| Times Cited | 10 |
| WOS Category | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | BALL-1(RCB0256) |