Reference - Detail
| RRC ID | 43324 |
|---|---|
| Author | Wang CY, Miyazaki N, Yamashita T, Higashiura A, Nakagawa A, Li TC, Takeda N, Xing L, Hjalmarsson E, Friberg C, Liou DM, Sung YJ, Tsukihara T, Matsuura Y, Miyamura T, Cheng RH. |
| Title | Crystallization and preliminary X-ray diffraction analysis of recombinant hepatitis E virus-like particle. |
| Journal | Acta Crystallogr Sect F Struct Biol Cryst Commun |
| Abstract |
Hepatitis E virus (HEV) accounts for the majority of enterically transmitted hepatitis infections worldwide. Currently, there is no specific treatment for or vaccine against HEV. The major structural protein is derived from open reading frame (ORF) 2 of the viral genome. A potential oral vaccine is provided by the virus-like particles formed by a protein construct of partial ORF3 protein (residue 70-123) fused to the N-terminus of the ORF2 protein (residues 112-608). Single crystals obtained by the hanging-drop vapour-diffusion method at 293 K diffract X-rays to 8.3 A resolution. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 337, b = 343, c = 346 A, alpha = beta = gamma = 90 degrees , and contain one particle per asymmetric unit. |
| Volume | 64(Pt 4) |
| Pages | 318-22 |
| Published | 2008-4-1 |
| DOI | 10.1107/S1744309108007197 |
| PII | S1744309108007197 |
| PMID | 18391436 |
| PMC | PMC2374242 |
| MeSH | Capsid Proteins / chemistry Capsid Proteins / genetics Crystallization Hepatitis E virus / chemistry* Hepatitis E virus / genetics Peptide Fragments / chemistry Peptide Fragments / genetics Recombinant Fusion Proteins / analysis Recombinant Fusion Proteins / chemistry* Recombinant Fusion Proteins / genetics Virion / chemistry* Virion / genetics X-Ray Diffraction* |
| IF | 0.968 |
| Times Cited | 13 |
| WOS Category | CRYSTALLOGRAPHY BIOPHYSICS BIOCHEMICAL RESEARCH METHODS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Human and Animal Cells | Sf9(RCB0569) |