論文 - 詳細
| RRC ID | 43332 |
|---|---|
| 著者 | Tamaki N, Matsunami K, Otsuka H, Shinzato T, Aramoto M, Takeda Y. |
| タイトル | Rearranged ent-kauranes from the stems of Tricalysia dubia and their biological activities. |
| ジャーナル | J Nat Med |
| Abstract |
From the EtOAc-soluble fraction of an MeOH extract of the stems of Tricalysia dubia, two new rearranged ent-kaurane derivatives, named tricalysiolides H and I, were isolated, together with five known rearranged ent-kauranes, i.e. tricalysiolides A-E, stigmast-4-en-6beta-ol-3-one, (+)-pinoresinol, scopoletin and syringaldehyde. Their structures were elucidated from spectroscopic evidence, and their cytotoxicity toward KB cells and P-gp inhibitory activity were assayed. |
| 巻・号 | 62(3) |
| ページ | 314-20 |
| 公開日 | 2008-7-1 |
| DOI | 10.1007/s11418-008-0248-x |
| PMID | 18409065 |
| MeSH | ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Diterpenes, Kaurane / isolation & purification Diterpenes, Kaurane / pharmacology* Drug Screening Assays, Antitumor Flow Cytometry Humans K562 Cells KB Cells Plant Extracts / isolation & purification Plant Extracts / pharmacology* Plant Stems Rubiaceae / chemistry* Spectrum Analysis |
| IF | 2.055 |
| 引用数 | 5 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | K562/Adr(RCB1898) |