論文 - 詳細
| RRC ID | 43340 |
|---|---|
| 著者 | Li F, Awale S, Tezuka Y, Kadota S. |
| タイトル | Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines. Based on the observed results, structure-activity relationships were discussed. Among the tested compounds, 7-hydroxy-6-methoxyflavanone (3) exhibited the most potent activity against B16-BL6 (IC(50), 6.66microM), LLC (IC(50), 9.29microM), A549 (IC(50), 8.63microM), and HT-1080 (IC(50), 7.94microM) cancer cell lines, and mucronulatol (26) against LLC (IC(50), 8.38microM) and A549 (IC(50), 9.9microM) cancer cell lines. These activity data were comparable to those of the clinically used anticancer drugs, 5-fluorouracil and doxorubicin, against the tested cell lines, suggesting that 3 and 26 are the good candidates for future anticancer drug development. |
| 巻・号 | 16(10) |
| ページ | 5434-40 |
| 公開日 | 2008-5-15 |
| DOI | 10.1016/j.bmc.2008.04.016 |
| PII | S0968-0896(08)00329-5 |
| PMID | 18440233 |
| MeSH | Animals Brazil Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Flavanones / chemistry Flavanones / isolation & purification Flavanones / pharmacology* Flavonoids / chemistry Flavonoids / isolation & purification Flavonoids / pharmacology* HeLa Cells Humans Inhibitory Concentration 50 Mice Molecular Structure Neoplasms / drug therapy* Propolis / chemistry* Stereoisomerism Structure-Activity Relationship |
| IF | 3.073 |
| 引用数 | 93 |
| WOS 分野 | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) A549(RCB0098) |