RRC ID |
43362
|
著者 |
Oyane A, Ishikawa Y, Yamazaki A, Sogo Y, Furukawa K, Ushida T, Ito A.
|
タイトル |
Reduction of surface roughness of a laminin-apatite composite coating via inhibitory effect of magnesium ions on apatite crystal growth.
|
ジャーナル |
Acta Biomater
|
Abstract |
An artificial material coated with a laminin-apatite composite layer on its surface would be useful as a percutaneous device with cell-adhesion properties and good biocompatibility. The present authors recently prepared such a composite by a liquid-phase coating process in which a surface-modified material was immersed in a laminin-containing calcium phosphate solution (LCP solution) supersaturated with respect to apatite. As a result of this coating process, however, the material increased in surface roughness, which may have an adverse effect on the prevention of bacterial infection. In the present study, a reduction of the surface roughness of the laminin-apatite composite layer was attempted by adding MgSO(4) to the LCP solution as an inhibitor of apatite crystal growth. The surface roughness, Ra, of the resulting laminin-apatite composite layer decreased from approximately 0.43 to 0.31mum upon increasing the MgSO(4) concentration in the LCP solution from 0 to 1.5mM, while retaining its cell adhesion characteristics. The thus-obtained material, having a laminin-apatite composite coating with reduced surface roughness, has potential as a material for percutaneous devices with improved resistance to bacterial infection through the interface between the device and the skin.
|
巻・号 |
4(5)
|
ページ |
1342-8
|
公開日 |
2008-9-1
|
DOI |
10.1016/j.actbio.2008.04.008
|
PII |
S1742-7061(08)00116-5
|
PMID |
18485843
|
MeSH |
Apatites / chemistry*
Cell Adhesion / drug effects
Cell Adhesion / physiology*
Cell Line
Coated Materials, Biocompatible / chemistry
Coated Materials, Biocompatible / pharmacology
Crystallization / methods*
Epithelial Cells / drug effects
Epithelial Cells / physiology*
Humans
Ions
Laminin / chemistry*
Laminin / pharmacology*
Magnesium / chemistry*
Materials Testing
Surface Properties
|
IF |
7.242
|
引用数 |
8
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
リソース情報 |
ヒト・動物細胞 |
|