| RRC ID |
43517
|
| Author |
Seki T, Morimura S, Ohba H, Tang Y, Shigematsu T, Maeda H, Kida K.
|
| Title |
Immunostimulation-mediated antitumor activity by preconditioning with rice-shochu distillation residue against implanted tumor in mice.
|
| Journal |
Nutr Cancer
|
| Abstract |
We investigated the ability of rice-shochu postdistillation residue (RSDR) to stimulate the activity of macrophages. RSDR significantly stimulated mouse macrophage activity and induced significant IL-12 production in vitro. In syngeneic C38 solid tumor model in mice, a diet containing 1.0% RSDR caused a significant suppression of tumor growth and prolonged the life span of the tumor-bearing mice. Further, using this model, mice fed for 21 days with RSDR showed significantly increased levels of serum IL-12 and IFN-gamma compared with controls. Moreover, the splenic NK cell activity of mice fed with RSDR was significantly elevated compared with that of mice on a normal diet and thereby suppressed C38 tumor growth. We also investigated the tumor growth suppressing effect of RSDR using a tumor model of B16-F10 melanoma cells. Dietary preconditioning with RSDR significantly suppressed B16-F10 tumor growth. Moreover, RSDR significantly increased the production of IL-12 either before or after B16-F10 tumor implantation. These results suggest that dietary RSDR suppresses tumor growth by stimulating the immune system of the host.
|
| Volume |
60(6)
|
| Pages |
776-83
|
| Published |
2008-1-1
|
| DOI |
10.1080/01635580802277709
|
| PII |
905459742
|
| PMID |
19005977
|
| MeSH |
Adjuvants, Immunologic / pharmacology*
Animals
Antineoplastic Agents / pharmacology*
Interferon-gamma / biosynthesis
Interleukin-12 / biosynthesis
Interleukin-2 / biosynthesis
Killer Cells, Natural / immunology
Lymphocyte Activation
Macrophages / immunology
Male
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Neoplasms, Experimental / drug therapy*
Neoplasms, Experimental / immunology
Oryza*
|
| IF |
2.363
|
| Times Cited |
7
|
|
WOS Category
|
NUTRITION & DIETETICS
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
YAC-1(RCB1165) |
