論文 - 詳細
| RRC ID | 43527 |
|---|---|
| 著者 | Hanyu K, Iida T, Shiba H, Ohashi T, Eto Y, Yanaga K. |
| タイトル | Immunogene therapy by adenovirus vector expressing CD40 ligand for metastatic liver cancer in rats. |
| ジャーナル | Anticancer Res |
| Abstract |
BACKGROUND:We have explored a gene-therapeutic approach to stimulate antitumor immunity by adenoviral-mediated transfer of CD40 ligand (CD40L) to treat metastatic liver cancer in a rat model. MATERIALS AND METHODS:Rat metastatic liver cancer cells were implanted into the back of rats bilaterally. When the larger tumor reached 8.0 mm in diameter, adenovirus vector-expressing mouse CD40L was injected intratumorally as treatment group (n=5), while LacZ was injected in the control group (n=5). RESULTS:In the control group, the tumor gradually grew to be 20.7+/-1.6 (mean+/-SD) mm in intratumorally injected tumors and 21.8+/-3.7 mm in opposite tumors seven weeks after injection, respectively. In contrast, in the treatment group, the tumor was reduced to 3.6+/-8.2 mm and 3.7+/-8.2 mm. The tumor growth and survival rate were significantly different (p<0.001). CONCLUSION:Adenovirus vector-mediated CD40L gene therapy is an effective therapeutic method for metastatic liver cancer. |
| 巻・号 | 28(5A) |
| ページ | 2785-9 |
| 公開日 | 2008-1-1 |
| PMID | 19035311 |
| MeSH | Adenoviridae / genetics Animals CD40 Ligand / biosynthesis CD40 Ligand / genetics* CD40 Ligand / immunology* Flow Cytometry Genetic Therapy / methods Genetic Vectors Immunogenetics / methods* Liver Neoplasms, Experimental / genetics Liver Neoplasms, Experimental / immunology* Liver Neoplasms, Experimental / secondary Liver Neoplasms, Experimental / therapy* Male Rats Rats, Inbred F344 |
| IF | 1.994 |
| 引用数 | 7 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | RCN-9(RCB0511) |