論文 - 詳細
| RRC ID | 43552 |
|---|---|
| 著者 | Li H, Ge Y, Zhang P, Wu L, Chen S. |
| タイトル | The effect of layer-by-layer chitosan-hyaluronic acid coating on graft-to-bone healing of a poly(ethylene terephthalate) artificial ligament. |
| ジャーナル | J Biomater Sci Polym Ed |
| Abstract |
Surface coating with an organic layer-by-layer self-assembled template of chitosan and hyaluronic acid on a poly(ethylene terephthalate) (PET) artificial ligament was designed for the promotion and enhancement of graft-to-bone healing after artificial ligament implantation in a bone tunnel. The results of in vitro culturing of MC3T3-E1 mouse osteoblastic cells supported the hypothesis that the layer-by-layer coating of chitosan and hyaluronic acid could promote the cell compatibility of grafts and could promote osteoblast proliferation. A rabbit extra-articular tendon-to-bone healing model was used to evaluate the effect of this kind of surface-modified stainless artificial ligament in vivo. The final results proved that this organic compound coating could significantly promote and enhance new bone formation at the graft-bone interface histologically and, correspondingly, the experimental group with coating had significantly higher biomechanical properties compared with controls at 8 weeks (P < 0.05). |
| 巻・号 | 23(1-4) |
| ページ | 425-38 |
| 公開日 | 2012-1-1 |
| DOI | 10.1163/092050610X551989 |
| PII | jbs3269 |
| PMID | 21255485 |
| MeSH | 3T3 Cells Animals Bone Transplantation / adverse effects* Bone and Bones / drug effects Bone and Bones / pathology Bone and Bones / surgery* Cell Proliferation / drug effects Chitosan / chemistry* Coated Materials, Biocompatible / chemistry Coated Materials, Biocompatible / pharmacology* Hyaluronic Acid / chemistry* Ligaments / drug effects* Ligaments / pathology Male Mechanical Phenomena Mice Polyethylene Terephthalates / chemistry* Rabbits Surface Properties Wound Healing / drug effects |
| IF | 2.69 |
| 引用数 | 27 |
| WOS 分野 | POLYMER SCIENCE ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |