| RRC ID |
43552
|
| Author |
Li H, Ge Y, Zhang P, Wu L, Chen S.
|
| Title |
The effect of layer-by-layer chitosan-hyaluronic acid coating on graft-to-bone healing of a poly(ethylene terephthalate) artificial ligament.
|
| Journal |
J Biomater Sci Polym Ed
|
| Abstract |
Surface coating with an organic layer-by-layer self-assembled template of chitosan and hyaluronic acid on a poly(ethylene terephthalate) (PET) artificial ligament was designed for the promotion and enhancement of graft-to-bone healing after artificial ligament implantation in a bone tunnel. The results of in vitro culturing of MC3T3-E1 mouse osteoblastic cells supported the hypothesis that the layer-by-layer coating of chitosan and hyaluronic acid could promote the cell compatibility of grafts and could promote osteoblast proliferation. A rabbit extra-articular tendon-to-bone healing model was used to evaluate the effect of this kind of surface-modified stainless artificial ligament in vivo. The final results proved that this organic compound coating could significantly promote and enhance new bone formation at the graft-bone interface histologically and, correspondingly, the experimental group with coating had significantly higher biomechanical properties compared with controls at 8 weeks (P < 0.05).
|
| Volume |
23(1-4)
|
| Pages |
425-38
|
| Published |
2012-1-1
|
| DOI |
10.1163/092050610X551989
|
| PII |
jbs3269
|
| PMID |
21255485
|
| MeSH |
3T3 Cells
Animals
Bone Transplantation / adverse effects*
Bone and Bones / drug effects
Bone and Bones / pathology
Bone and Bones / surgery*
Cell Proliferation / drug effects
Chitosan / chemistry*
Coated Materials, Biocompatible / chemistry
Coated Materials, Biocompatible / pharmacology*
Hyaluronic Acid / chemistry*
Ligaments / drug effects*
Ligaments / pathology
Male
Mechanical Phenomena
Mice
Polyethylene Terephthalates / chemistry*
Rabbits
Surface Properties
Wound Healing / drug effects
|
| IF |
2.69
|
| Times Cited |
27
|
|
WOS Category
|
POLYMER SCIENCE
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
