Reference - Detail
| RRC ID | 4356 |
|---|---|
| Author | Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K. |
| Title | Progress and prospects in rat genetics: a community view. |
| Journal | Nat Genet |
| Abstract |
The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing of the rat genome, ushering in an era of exceptional opportunity for identifying genes and pathways underlying disease phenotypes. Genome-wide association studies in human populations have recently provided a direct approach for finding robust genetic associations in common diseases, but identifying the precise genes and their mechanisms of action remains problematic. In the context of significant progress in rat genomic resources over the past decade, we outline achievements in rat gene discovery to date, show how these findings have been translated to human disease, and document an increasing pace of discovery of new disease genes, pathways and mechanisms. Finally, we present a set of principles that justify continuing and strengthening genetic studies in the rat model, and further development of genomic infrastructure for rat research. |
| Volume | 40(5) |
| Pages | 516-22 |
| Published | 2008-5-1 |
| DOI | 10.1038/ng.147 |
| PII | ng.147 |
| PMID | 18443588 |
| MeSH | Animals Animals, Genetically Modified Chromosome Mapping Disease Models, Animal* Gene Targeting Genetic Diseases, Inborn / genetics* Genome* Genomics / trends* Humans Rats / genetics* |
| IF | 27.605 |
| Times Cited | 212 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 31 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Rats | review |