| RRC ID |
43623
|
| Author |
Poulose AC, Veeranarayanan S, Mohamed MS, Raveendran S, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS.
|
| Title |
PEG coated biocompatible cadmium chalcogenide quantum dots for targeted imaging of cancer cells.
|
| Journal |
J Fluoresc
|
| Abstract |
Cancer stands as a leading cause of mortality worldwide and diagnostics of cancer still faces drawbacks. Optical imaging of cancer would allow early diagnosis, evaluation of disease progression and therapy efficiency. To that aim, we have developed highly biocompatible PEG functionalized cadmium chalcogenide based three differently luminescent quantum dots (QDs) (CdS, CdSe and CdTe). Folate targeting scheme was utilized for targeting cancer cell line, MCF-7. We demonstrate the biocompatibility, specificity and efficiency of our nanotool in detection of cancer cells sparing normal cell lines with retained fluorescence of functionalized QDs as parental counterpart. This is the first time report of utilizing three differently fluorescent QDs and we have detailed about the internalization of these materials and time dependent saturation of targeting schemes. We present here the success of utilizing our biocompatible imaging tool for early diagnosis of cancer.
|
| Volume |
22(3)
|
| Pages |
931-44
|
| Published |
2012-5-1
|
| DOI |
10.1007/s10895-011-1032-y
|
| PMID |
22227700
|
| MeSH |
Cadmium / chemistry*
Cell Proliferation
Chalcogens / chemistry*
Coated Materials, Biocompatible / analysis*
Coated Materials, Biocompatible / chemical synthesis
Coated Materials, Biocompatible / chemistry
Humans
Luminescent Agents / analysis*
Luminescent Agents / chemical synthesis
Luminescent Agents / chemistry
Molecular Imaging / methods*
Neoplasms / diagnosis*
Neoplasms / pathology
Particle Size
Polyethylene Glycols / chemistry*
Quantum Dots*
Surface Properties
Tumor Cells, Cultured
|
| IF |
2.093
|
| Times Cited |
16
|
|
WOS Category
|
CHEMISTRY, ANALYTICAL
BIOCHEMICAL RESEARCH METHODS
CHEMISTRY, PHYSICAL
|
| Resource |
| Human and Animal Cells |
|
