Reference - Detail
| RRC ID | 43631 |
|---|---|
| Author | Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y. |
| Title | Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes. |
| Journal | FEBS Lett |
| Abstract |
In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity. |
| Volume | 586(4) |
| Pages | 368-72 |
| Published | 2012-2-17 |
| DOI | 10.1016/j.febslet.2012.01.001 |
| PII | S0014-5793(12)00014-2 |
| PMID | 22245676 |
| MeSH | 3T3-L1 Cells Adipocytes / drug effects Adipocytes / metabolism Adiponectin / genetics Adipose Tissue / metabolism* Animals Cell Line Coculture Techniques Decanoic Acids / pharmacology Fatty Acids / metabolism Gene Expression / drug effects Inflammation / genetics* Inflammation / metabolism Ligands Macrophages / metabolism Male Mice Mice, Inbred C57BL RNA, Messenger / genetics RNA, Messenger / metabolism Receptors, G-Protein-Coupled / genetics* Receptors, G-Protein-Coupled / metabolism Tumor Necrosis Factor-alpha / pharmacology* |
| IF | 3.057 |
| Times Cited | 47 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 23 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |