論文 - 詳細
| RRC ID | 43655 |
|---|---|
| 著者 | Lian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, Yasutomo K. |
| タイトル | Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice. |
| ジャーナル | J Immunol |
| Abstract |
The interplay of CD4(+) and CD8(+) T cells targeting autoantigens is responsible for the progression of a number of autoimmune diseases, including type 1 diabetes mellitus (T1D). Understanding the molecular mechanisms that regulate T cell activation is crucial for designing effective therapies for autoimmune diseases. We probed a panel of Abs with T cell-modulating activity and identified a mAb specific for the H chain of CD98 (CD98hc) that was able to suppress T cell proliferation. The anti-CD98hc mAb also inhibited Ag-specific proliferation and the acquisition of effector function by CD4(+) and CD8(+) T cells in vitro and in vivo. Injection of the anti-CD98hc mAb completely prevented the onset of cyclophosphamide-induced diabetes in NOD mice. Treatment of diabetic NOD mice with anti-CD98hc reversed the diabetic state to normal levels, coincident with decreased proliferation of CD4(+) T cells. Furthermore, treatment of diabetic NOD mice with CD98hc small interfering RNA resolved T1D. These data indicate that strategies targeting CD98hc might have clinical application for treating T1D and other T cell-mediated autoimmune diseases. |
| 巻・号 | 188(5) |
| ページ | 2227-34 |
| 公開日 | 2012-3-1 |
| DOI | 10.4049/jimmunol.1102586 |
| PII | jimmunol.1102586 |
| PMID | 22291182 |
| MeSH | Animals Antibodies, Monoclonal / administration & dosage Antibodies, Monoclonal / therapeutic use CD4-Positive T-Lymphocytes / immunology CD4-Positive T-Lymphocytes / metabolism CD4-Positive T-Lymphocytes / pathology CD8-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / metabolism CD8-Positive T-Lymphocytes / pathology Cyclophosphamide / administration & dosage Diabetes Mellitus, Type 1 / chemically induced Diabetes Mellitus, Type 1 / immunology* Diabetes Mellitus, Type 1 / prevention & control* Female Fusion Regulatory Protein 1, Heavy Chain / genetics Fusion Regulatory Protein 1, Heavy Chain / immunology Fusion Regulatory Protein 1, Heavy Chain / physiology* Growth Inhibitors / genetics Growth Inhibitors / metabolism Growth Inhibitors / physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Mice, Transgenic Rats Rats, Wistar |
| IF | 4.886 |
| 引用数 | 5 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | SP2/0-Ag14(RCB020) |