| RRC ID |
43656
|
| 著者 |
Hatata T, Higaki K, Tatebe S, Shomori K, Ikeguchi M.
|
| タイトル |
Immunohistochemical study of nuclear factor-κB expression in esophageal squamous cell carcinoma: prognostic significance and sensitivity to treatment with 5-FU.
|
| ジャーナル |
Dis Esophagus
|
| Abstract |
Nuclear factor-κB (NF-κB) is expressed in many types of cancers. It has been suggested that the expression of NF-κB is associated with poor prognosis and resistance to chemoradiation therapies. This study evaluated the relationship between the expression of NF-κB and the prognosis and sensitivity of esophageal squamous cell carcinoma (ESCC) to chemotherapy. One hundred and nine ESCC specimens, from patients who had undergone radical esophagectomy, were divided into two groups depending on the expression of NF-κB. Surgical data and prognosis were compared between the two groups. NF-κB-positive tumors were detected in 61.5% of the cases. In 69 patients with stage II and III disease, 41 patients who were NF-κB-positive showed poor survival. The sensitivity of esophageal squamous cell carcinoma cell lines to 5-fluorouracil (5-FU) was analyzed by their NF-κB expression, and the effect of 5-FU was evaluated on the proliferation and activity of two cell lines of cultured ESCCs expressing NF-κB. ESCCs with activated NF-κB had poor sensitivity to 5-FU. These results suggest that the increased expression of NF-κB is associated with poor prognosis in patients with ESCC. NF-κB may be a target for ESCC therapy because of its selective expression in this type of cancer.
|
| 巻・号 |
25(8)
|
| ページ |
716-22
|
| 公開日 |
2012-1-1
|
| DOI |
10.1111/j.1442-2050.2011.01308.x
|
| PMID |
22292507
|
| MeSH |
Aged
Aged, 80 and over
Antimetabolites, Antineoplastic / pharmacology
Antimetabolites, Antineoplastic / therapeutic use*
Apoptosis / drug effects
Biomarkers, Tumor / metabolism*
Carcinoma, Squamous Cell / drug therapy
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / pathology
Cell Line, Tumor
Cell Proliferation / drug effects
Disease-Free Survival
Esophageal Neoplasms / drug therapy
Esophageal Neoplasms / metabolism*
Esophageal Neoplasms / pathology
Female
Fluorouracil / pharmacology
Fluorouracil / therapeutic use*
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
NF-kappa B / metabolism*
Retrospective Studies
Transcription, Genetic / drug effects
|
| IF |
2.386
|
| 引用数 |
12
|
|
WOS 分野
|
GASTROENTEROLOGY & HEPATOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
TE-4(RCB2097)
TE-8(RCB2098) |
