論文 - 詳細
| RRC ID | 43723 |
|---|---|
| 著者 | Usui F, Kimura H, Ohshiro T, Tatsumi K, Kawashima A, Nishiyama A, Iwakura Y, Ishibashi S, Takahashi M. |
| タイトル | Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
OBJECTIVE:Several reports describe the role of interleukin (IL)-17 in the development of atherosclerosis; however, its precise role remains controversial. We generated double-deficient mice for apolipoprotein E (apoE) and IL-17 (apoE(-/-)IL-17(-/-) mice) and investigated the effect of IL-17 deficiency on vascular inflammation and atherosclerosis. METHODS AND RESULTS:Atherosclerotic plaque areas in apoE(-/-)IL-17(-/-) mice fed a Western diet (WD) were significantly reduced compared with those in apoE(-/-) mice. No significant differences in plasma lipid profiles were observed between apoE(-/-) and apoE(-/-)IL-17(-/-) mice. The number of infiltrated macrophages in the plaques was significantly decreased in WD-fed apoE(-/-)IL-17(-/-) mice compared with WD-fed apoE(-/-) mice, whereas vascular smooth muscle cell content was not altered by IL-17 deficiency. Expression of inflammatory cytokines (MCP-1, IL-1β, IL-6, IFN-γ, and IL-12 p40) and scavenger receptors (Msr-1, Scarb1, and Olr1) in the plaques was inhibited in WD-fed apoE(-/-)IL-17(-/-) mice. Furthermore, expression of inducible nitric oxide (M1 marker) and arginase-1 (M2 marker) was inhibited in WD-fed apoE(-/-)IL-17(-/-) mice. CONCLUSION:Our results indicate that IL-17 deficiency reduces vascular inflammation and atherosclerosis and that modulation of IL-17 could be a potential target for prevention and treatment of atherosclerosis. |
| 巻・号 | 420(1) |
| ページ | 72-7 |
| 公開日 | 2012-3-30 |
| DOI | 10.1016/j.bbrc.2012.02.117 |
| PII | S0006-291X(12)00376-2 |
| PMID | 22402284 |
| MeSH | Animals Apolipoproteins E / genetics Atherosclerosis / genetics Atherosclerosis / immunology* Cytokines / biosynthesis Diet / adverse effects Disease Models, Animal Interleukin-17 / genetics* Macrophages / immunology Male Mice Mice, Inbred C57BL Mice, Mutant Strains Vasculitis / genetics Vasculitis / immunology* |
| IF | 2.985 |
| 引用数 | 40 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |