論文 - 詳細
| RRC ID | 43737 |
|---|---|
| 著者 | Shiratori B, Zhang J, Usami O, Chagan-Yasutan H, Suzuki Y, Nakajima C, Uede T, Hattori T. |
| タイトル | Quinolone-induced upregulation of osteopontin gene promoter activity in human lung epithelial cell line A549. |
| ジャーナル | Antimicrob Agents Chemother |
| Abstract |
Quinolones, in addition to their antibacterial activities, act as immunomodulators. Osteopontin (OPN), a member of the extracellular matrix proteins, was found to play a role in the immune and inflammatory response. We found that quinolones significantly enhanced OPN secretion, namely, garenoxacin (220%), moxifloxacin (62%), gatifloxacin (82%), sparfloxacin, (79%), and sitafloxacin (60%). Enhancement of OPN secretion was shown to be due to the effect of quinolones on the OPN gene promoter activity. We also examined the role of quinolones on apoptosis and found that sparfloxacin decreased the late apoptosis of A549 cells, but garenoxacin did not show the antiapoptotic effect. The antiapoptotic effects of quinolones do not appear to be associated with OPN elevation. |
| 巻・号 | 56(6) |
| ページ | 2868-72 |
| 公開日 | 2012-6-1 |
| DOI | 10.1128/AAC.06062-11 |
| PII | AAC.06062-11 |
| PMID | 22430970 |
| PMC | PMC3370769 |
| MeSH | Apoptosis / drug effects Cell Line Cell Survival / drug effects Flow Cytometry Humans Osteopontin / genetics* Osteopontin / metabolism* Promoter Regions, Genetic / drug effects* Promoter Regions, Genetic / genetics* Quinolones / pharmacology* Reverse Transcriptase Polymerase Chain Reaction |
| IF | 4.904 |
| 引用数 | 2 |
| WOS 分野 | PHARMACOLOGY & PHARMACY MICROBIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |