論文 - 詳細
| RRC ID | 43743 |
|---|---|
| 著者 | Imai M, Takahashi N. |
| タイトル | Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma. |
| ジャーナル | Bioorg Med Chem |
| Abstract |
Pancreatic cancer and cholangiocarcinoma are aggressive and drug-resistant refractory cancers. Based on N-(4-hydroxyphenyl)retinamide (3), a synthetic amide of all-trans-retinoic acid (RA), p-dodecylaminophenol (1) was developed to be an effective anticancer agent without key side-effects of these agents. Compound 1 suppresses cell growth of pancreatic cancer (MIA Paca2) and cholangiocarcinoma (HuCCT1), potentially by inhibiting ras expression and signaling through ERK pathways in MIA Paca2 cells and both ERK and Akt pathways in HuCCT1 cells. Compound 1 inhibits proliferation of these cells to a greater extent than either RA or 3. Compound 1 may represent a potent and useful anti-cancer drug for use against pancreatic cancer and cholangiocarcinoma that lacks their key side-effects. |
| 巻・号 | 20(8) |
| ページ | 2520-6 |
| 公開日 | 2012-4-15 |
| DOI | 10.1016/j.bmc.2012.02.060 |
| PII | S0968-0896(12)00178-2 |
| PMID | 22440084 |
| MeSH | Aminophenols / chemical synthesis Aminophenols / chemistry Aminophenols / pharmacology* Antineoplastic Agents / chemical synthesis Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology* Cell Proliferation / drug effects Cholangiocarcinoma / drug therapy* Cholangiocarcinoma / pathology Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Structure Pancreatic Neoplasms / drug therapy* Pancreatic Neoplasms / pathology Structure-Activity Relationship Tumor Cells, Cultured |
| IF | 3.073 |
| 引用数 | 4 |
| WOS 分野 | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |