| RRC ID |
43793
|
| Author |
Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H.
|
| Title |
Promotion of hair growth by Rosmarinus officinalis leaf extract.
|
| Journal |
Phytother Res
|
| Abstract |
Topical administration of Rosmarinus officinalis leaf extract (RO-ext, 2 mg/day/mouse) improved hair regrowth in C57BL/6NCrSlc mice that experienced hair regrowth interruption induced by testosterone treatment. In addition, RO-ext promoted hair growth in C3H/He mice that had their dorsal areas shaved. To investigate the antiandrogenic activity mechanism of RO-ext, we focused on inhibition of testosterone 5α-reductase, which is well recognized as one of the most effective strategies for the treatment of androgenic alopecia. RO-ext showed inhibitory activity of 82.4% and 94.6% at 200 and 500 µg/mL, respectively. As an active constituent of 5α-reductase inhibition, 12-methoxycarnosic acid was identified with activity-guided fractionation. In addition, the extract of R. officinalis and 12-methoxycarnosic acid inhibited androgen-dependent proliferation of LNCaP cells as 64.5% and 66.7% at 5 µg/mL and 5 μM, respectively. These results suggest that they inhibit the binding of dihydrotestosterone to androgen receptors. Consequently, RO-ext is a promising crude drug for hair growth.
|
| Volume |
27(2)
|
| Pages |
212-7
|
| Published |
2013-2-1
|
| DOI |
10.1002/ptr.4712
|
| PMID |
22517595
|
| MeSH |
5-alpha Reductase Inhibitors / pharmacology*
Alopecia / chemically induced
Alopecia / drug therapy
Androgen Antagonists / pharmacology
Animals
Cell Line, Tumor
Hair / drug effects*
Hair / growth & development
Humans
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Phytotherapy
Plant Extracts / pharmacology*
Plant Leaves / chemistry
Rats
Rats, Wistar
Rosmarinus / chemistry*
Testosterone / pharmacology
|
| IF |
4.087
|
| Times Cited |
18
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
LNCap.FGC(RCB2144) |
