論文 - 詳細
| RRC ID | 43795 |
|---|---|
| 著者 | Sakamoto N, Uemae Y, Ishikawa E, Takano S, Nakai K, Yamamoto T, Zaboronok A, Matsumura A. |
| タイトル | Glioma immunotherapy with combined autologous tumor cell and endothelial cell vaccine in vivo. |
| ジャーナル | Neurol Med Chir (Tokyo) |
| Abstract |
Combined vaccines containing GL261 murine glioma cells and F-2 murine endothelial cells fixed with glutaraldehyde-phosphate buffered saline were injected into the intradermal tissue of the tail base of C57BL/6 mice. After the vaccination, GL261 cells were injected subcutaneously into the left flank of the mice. Vaccination with fixed F-2 cells induced the development of relatively high amounts of interferon-gamma-releasing cells after in vitro re-stimulation with vascular endothelial growth factor-receptor 2 peptide. Tumor growth was inhibited after preventive use of the combined vaccine, prepared from GL261 and F-2 cells. Tumor specimens obtained from the combined vaccine group in a therapeutic experiment showed significantly decreased vessel count. Glioma immunotherapy with a combined vaccine prepared from tumor cells and endothelial cells might represent a new clinical strategy, as such combinations may theoretically affect both high-grade glioma cells and their environment. |
| 巻・号 | 52(4) |
| ページ | 194-201 |
| 公開日 | 2012-1-1 |
| DOI | 10.2176/nmc.52.194 |
| PII | JST.JSTAGE/nmc/52.194 |
| PMID | 22522329 |
| MeSH | Animals Brain Neoplasms / blood supply Brain Neoplasms / immunology Brain Neoplasms / therapy* Cancer Vaccines / immunology Cancer Vaccines / pharmacology* Cell Line, Tumor Cell Transplantation / methods* Glioma / blood supply Glioma / immunology Glioma / therapy* Immunotherapy / methods Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Transplantation / methods Neoplasms, Experimental / immunology Neoplasms, Experimental / physiopathology Neoplasms, Experimental / therapy* Primary Cell Culture Vaccines, Combined / immunology Vaccines, Combined / pharmacology* |
| IF | 1.836 |
| 引用数 | 2 |
| WOS 分野 | CLINICAL NEUROLOGY SURGERY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Tpit/E(RCB1692) |