| RRC ID |
43795
|
| 著者 |
Sakamoto N, Uemae Y, Ishikawa E, Takano S, Nakai K, Yamamoto T, Zaboronok A, Matsumura A.
|
| タイトル |
Glioma immunotherapy with combined autologous tumor cell and endothelial cell vaccine in vivo.
|
| ジャーナル |
Neurol Med Chir (Tokyo)
|
| Abstract |
Combined vaccines containing GL261 murine glioma cells and F-2 murine endothelial cells fixed with glutaraldehyde-phosphate buffered saline were injected into the intradermal tissue of the tail base of C57BL/6 mice. After the vaccination, GL261 cells were injected subcutaneously into the left flank of the mice. Vaccination with fixed F-2 cells induced the development of relatively high amounts of interferon-gamma-releasing cells after in vitro re-stimulation with vascular endothelial growth factor-receptor 2 peptide. Tumor growth was inhibited after preventive use of the combined vaccine, prepared from GL261 and F-2 cells. Tumor specimens obtained from the combined vaccine group in a therapeutic experiment showed significantly decreased vessel count. Glioma immunotherapy with a combined vaccine prepared from tumor cells and endothelial cells might represent a new clinical strategy, as such combinations may theoretically affect both high-grade glioma cells and their environment.
|
| 巻・号 |
52(4)
|
| ページ |
194-201
|
| 公開日 |
2012-1-1
|
| DOI |
10.2176/nmc.52.194
|
| PII |
JST.JSTAGE/nmc/52.194
|
| PMID |
22522329
|
| MeSH |
Animals
Brain Neoplasms / blood supply
Brain Neoplasms / immunology
Brain Neoplasms / therapy*
Cancer Vaccines / immunology
Cancer Vaccines / pharmacology*
Cell Line, Tumor
Cell Transplantation / methods*
Glioma / blood supply
Glioma / immunology
Glioma / therapy*
Immunotherapy / methods
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasm Transplantation / methods
Neoplasms, Experimental / immunology
Neoplasms, Experimental / physiopathology
Neoplasms, Experimental / therapy*
Primary Cell Culture
Vaccines, Combined / immunology
Vaccines, Combined / pharmacology*
|
| IF |
1.836
|
| 引用数 |
2
|
|
WOS 分野
|
CLINICAL NEUROLOGY
SURGERY
|
| リソース情報 |
| ヒト・動物細胞 |
|
