論文 - 詳細
| RRC ID | 43796 |
|---|---|
| 著者 | Kok YY, Mooi LY, Ahmad K, Sukari MA, Mat N, Rahmani M, Ali AM. |
| タイトル | Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii S. |
| ジャーナル | Molecules |
| Abstract |
Girinimbine, a carbazole alkaloid isolated from the stem bark of Murraya koenigii was tested for the in vitro anti-tumour promoting and antioxidant activities. Anti-tumour promoting activity was determined by assaying the capability of this compound to inhibit the expression of early antigen of Epstein-Barr virus (EA-EBV) in Raji cells that was induced by the tumour promoter, phorbol 12-myristate 13-acetate. The concentration of this compound that gave an inhibition rate at fifty percent was 6.0 µg/mL and was not cytotoxic to the cells. Immunoblotting analysis of the expression of EA-EBV showed that girinimbine was able to suppress restricted early antigen (EA-R). However, diffused early antigen (EA-D) was partially suppressed when used at 32.0 µg/mL. Girinimbine exhibited a very strong antioxidant activity as compared to a-tocopherol and was able to inhibit superoxide generation in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiated premyelocytic HL-60 cells more than 95%, when treated with the compound at 5.3 and 26.3 µg/mL, respectively. However girinimbine failed to scavenge the stable diphenyl picryl hydrazyl (DPPH)-free radical. |
| 巻・号 | 17(4) |
| ページ | 4651-60 |
| 公開日 | 2012-4-20 |
| DOI | 10.3390/molecules17044651 |
| PII | molecules17044651 |
| PMID | 22522395 |
| PMC | PMC6268782 |
| MeSH | Alkaloids / isolation & purification Alkaloids / pharmacology* Antigens, Viral / genetics Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Antioxidants / isolation & purification Antioxidants / pharmacology* Cell Line, Tumor Cell Survival / drug effects Gene Expression / drug effects Humans Murraya / chemistry* Plant Bark / chemistry* Plant Stems / chemistry* Superoxides / metabolism |
| IF | 3.267 |
| 引用数 | 19 |
| WOS 分野 | CHEMISTRY, ORGANIC |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |